Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers: ATRA treatment
Pathophysiology:
 • Cytokine Release from blast cells → SIRS response
 • Cathepsin G release → vascular permeability and endothelial damage
 • Induce blast cell adhesion and endothelial damage
Prophylaxis:
 • Attempt if high risk if WBC > 5 or elevated Cr
 • Prednisone 5mg/kg/day vs. 2.5 mg/m2
Presentation: Subacute-Acute:
 • Common: fever, myalgias, HoTN, edema and effusions, weight gain. More common in severe
 • Rare: DAH, acute febrile neutrophilic dermatosis
Diagnosis:
 • Labs: leukocytosis and coagulopathy common
 • Imaging: CXR- pulmonary opacities
 • Diagnosis: >3 symptoms, or> 1 with no other explanation. Moderate > 2/3 and severe >4. Timing, generally either within 6 days or 15 days of ATRA initiation
 • Differential Diagnosis: Infection (sepsis), PE, DAH, CHF, Anaphylaxis, Acute Renal Failure
Treatment:
 • Steroids: IV Dexamethasone 10 mg q12h -> 10 mg q6h
 • Cytoreductive: hydroxycarbamide 500 mg QD until normal WBC
 • Continue ATRA unless severe APLS, organ dysfuxtion, ICU, refractory to steroids
 • Supportive Care: Diuresis for fluid overload, PCC to reverse coagulopathy, RRT/IMV as needed

- Dr. Noah Rosenberg @nsrosenberg

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