Differentiation Syndrome in APML
Epidemiology:
• Incidence: common in APL (2-48% depending on the study)
• Triggers: ATRA treatment
Pathophysiology:
• Cytokine Release from blast cells → SIRS response
• Cathepsin G release → vascular permeability and endothelial damage
• Induce blast cell adhesion and endothelial damage
Prophylaxis:
• Attempt if high risk if WBC > 5 or elevated Cr
• Prednisone 5mg/kg/day vs. 2.5 mg/m2
Presentation: Subacute-Acute:
• Common: fever, myalgias, HoTN, edema and effusions, weight gain. More common in severe
• Rare: DAH, acute febrile neutrophilic dermatosis
Diagnosis:
• Labs: leukocytosis and coagulopathy common
• Imaging: CXR- pulmonary opacities
• Diagnosis: >3 symptoms, or> 1 with no other explanation. Moderate > 2/3 and severe >4. Timing, generally either within 6 days or 15 days of ATRA initiation
• Differential Diagnosis: Infection (sepsis), PE, DAH, CHF, Anaphylaxis, Acute Renal Failure
Treatment:
• Steroids: IV Dexamethasone 10 mg q12h -> 10 mg q6h
• Cytoreductive: hydroxycarbamide 500 mg QD until normal WBC
• Continue ATRA unless severe APLS, organ dysfuxtion, ICU, refractory to steroids
• Supportive Care: Diuresis for fluid overload, PCC to reverse coagulopathy, RRT/IMV as needed
- Dr. Noah Rosenberg @nsrosenberg
#Differentiation #Syndrome #APML #diagnosis #management #hematology #oncology