Classification of Some Antimicrobial Agents by Their Sites of Action
Inhibitors of metabolism: Sulfonamides, Trimethoprim
Inhibitors of cell wall synthesis: ß-Lactams, Vancomycin, Daptomycin, Telavancin, Fosfomycin
Inhibitors of protein synthesis: Tetracyclines, Aminoglycosides, Macrolides, Clindamycin, Chloramphenicol, Linezolid
Inhibitors of nucleic acid function or synthesis: Fluoroquinolones, Rifampin
Inhibitors of cell membrane function: Isoniazid, Amphotericin B, Polymyxins
#antimicrobial #mechanism #sites #action #pharmacology #antibiotics
Colony Morphology in Microbiology
1. Size - Punctiform, Small, Moderate, Large
2. Color
3. Texture - Dry, Smooth, Viscid, Mucoid
4. Elevation - Flat, Raised, Convex, Umbonate, Crateriform, Draughtsman Colony
5. Form - Round, Irregular, Filamentous, Rhizoid, Punctiform
6. Margin - Entire, Lobate, Scalloped, Filiform, Undulate, Curled, Serrate
- Cullen Lilley, MS, MDxT(AAB) @cullen_lilley
#Colony #Morphology #Microbiology #morphologies #description #diagnosis
Antibiotics - Mechanisms and Sites of Action
Inhibit Cell Wall Synthesis or Function
- Beta Lactams, Vancomycin, Daptomycin, Polypeptides
Inhibit Protein Synthesis 50S subunit
- Macrolides, Clindamycin, Linezolid, Streptogramins, Chloramphenicol
Inhibit Protein Synthesis 30S Subunit
- Aminoglycosides, Tetracyclines, Tigecycline
Inhibit Nucleic Acid Synthesis or Function
Inhibit DNA Gyrase +/- Topoisomerase IV: Quinolones
Inhibits Folate Synthesis: Trimethoprim / Sulfamethoxazole
Create Free Radicals: Metronidazole, Nitrofurantoin
- Dr. Eric Strong @DrEricStrong - Strong Medicine
#Mechanisms #Sites #Action #Pharmacology #Antibiotics #Bacteria
Gram Positive Cocci - Bacteria Identification Algorithm
Catalase(+)
- Coag(+): Staphylococcus aureus
- Coag(-)
- Oxidase(+), Bacitracin(S): Micrococcus sp
- Oxidase(-), Bacitracin(R)
- Novo(S): Staphylococcus lugdunensis, Staphylococcus epidermidis and CONS
- Novo(R): Staphylococcus saprophyticus
Catalase(-)
- Esculin(-)
- α-Heme
- Optochin(S): Streptococcus pneumoniae
- Optochin(R): Viridans Strep.
- β-Heme
- Bacitracin(S): Streptococcus pyogenes (GAS)
- Bacitracin(R): Streptococcus agalactiae (GBS)
- Esculin(+), α/β/γ Hemolysis
- 6.5% NaCl(+): Enterococcus sp.
- 6.5% NaCl(-): Non-Enterococcus Group D Streptococci
by Cullen Lilley, MS, MDxT(AAB) @cullen_lilley
#GramPositive #cocci #gpc #identification #algorithm #microbiology #bacteria #diagnosis