Unintentional Weight Loss in Primary Care • Definition: More than 5% reduction in body weight within 6-12 months, Is associated with increased morbidity and mortality • Baseline evaluation: CBC, BMP, LFTs, TSH, Glucose, CRP, ESR, LDH, UA Most Common Causes: - Malignancy (19% to 36%) - Unknown (6% to 28%) - Psychiatric (9% to 24%) - Nonmalignant gastrointestinal disease (9% to 19%) - Endocrine (4% to 11%) - Cardiopulmonary (9% to 10%) - Alcohol-related disease (8%) - Infectious disease (4% to 8%) - Neurologic (7%) - Rheumatic disease (7%) - Renal disease (4%) - Systemic inflammatory disorders (4%) - BWH Medicine Chiefs @BrighamChiefs #Unintentional #WeightLoss #PrimaryCare #diagnosis #differential #unexpected
