Who to test for BRCA 1/2? Female Breast Cancer: • ≤ 45-50 years at diagnosis • Triple Negative, age ≤ 60 years • Any age and Ashkenazi Jewish • 2 primary breast cancers, first at age 60 years old • Breast cancer + relative with breast cancer at age 50 years old, other cancers in this table Other Cancers: • Male Breast cancer • Invasive ovarian, fallopian tube, primary peritoneal cancer • Exocrine pancreatic cancer • Metastatic prostate cancer • High Grade Gleason (>7) prostate cancer and: Ashkenazi Jewish or other risk factors in this table Other: • 1st or 2nd degree relative meeting criteria for testing • Biological relative with BRCA 1/2 • Probability BRCA 1/2 >5% (as per risk assessment) • Ashkenazi Jewish adults - BWH Medicine Chiefs @BrighamChiefs #BRCA #testing #indications #oncology #Breast #Cancer #screening #diagnosis
