Acute Schistosomiasis: Katayama Fever • Most common in travelers and children • "Swimmers Itch" in the lower extremities, papular or urticarial rash • Systemic hypersensitivity reaction to the schistosome antigens and circulating immune complexes—coincides with beginning of egg production and rapid increase in Ag burden (3-8 weeks post exposure) • Fever, myalgias, arthralgias, diarrhea, abdominal pain, headache, rarely angioedema. Hepatomegaly and splenomegaly • Eosinophilia in 30-60% BWH Medicine Chiefs @BrighamChiefs #Schistosomiasis #Katayama #Fever #diagnosis #clinical #photo