Hepatobiliary Manifestations of Sickle Cell Disease Acute sickle cell hepatic crisis: • Fever, acute onset RUQ pain, jaundice and tender hepatomegaly • Supportive with treatment of SCD crisis Acute Hepatic sequestration: • Acute onset RUQ pain, hepatomegaly and anemia • Supportive with blood or exchange transfusion Acute intrahepatic cholestasis: • Fever, RUQ pain rapidly progressing to acute liver failure • Supportive, exchange transfusion, correction of coagulopathy? Liver transplant BWH Medicine Chiefs @BrighamChiefs #SickleCell #Disease #Hepatobiliary #hepatology #hepatitis #differential #diagnosis
