Powassan Virus Infection • Prodrome +/- fine erythematous rash → sudden onset fever, neurological deficits • Dx: PCR → IgM → IgG • Tx: Supportive, aggressive rehab • Encephalitis 10% fatality • 50% prolonged rehab for neuro deficits Summertime. 79M w/ malaise, R arm pronator drift & dysarthria -> fever & obtundation. MRI head with rhomboencephalitis, LP with lymphocytic pleocytosis, cultures negative, BUT +Powassan gene sequencing! - BWH Medicine Chiefs @BrighamChiefs #Powassan #Virus #Infection #diagnosis #management #neurology