Review of the Coagulation Cascade Traditional Model: • Parallel extrinsic and intrinsic pathways. Contemporary Model: • 4 key multicomponent complexes, each of which consists of an activated clotting factor enzyme, a cofactor, and the enzyme substrate. • Initiation phase caused by tissue factor's exposure due to vascular injury • Followed by the amplification phase (dependent upon intrinsic X-ase; factors VIII & IX) End result in both models (i.e. common pathway): Thrombin converts fibrinogen to fibrin, which is cross-linked by Factor XIIIa, resulting in coagulation - Dr. Eric Strong @DrEricStrong - Strong Medicine https://www.youtube.com/c/EricsMedi #Coagulation #Cascade #diagnosis #models #hematology #pathophysiology
