Mixing Study • Clotting tests can be abnormal due to either a clotting factor deficiency, or an inhibitor of normal factor activity (e.g. antibody). • A mixing study differentiates between deficiencies and inhibitors. • Clotting tests generally only require factors to have 50% of normal activity in order for the test to be normal. 1:1 Mix of Patient's Plasma + Pooled Normal Plasma → Recheck abnormal clotting test (e.g. PT and/or aPTT) • Clotting test normalizes → Patient has a factor deficiency • Clotting test does not normalize → Patient has a factor inhibitor - Dr. Eric Strong @DrEricStrong - Strong Medicine https://www.youtube.com/c/EricsMedi #Mixing #Study #diagnosis #hematology #pathophysiology #hematology #laboratory
