Adult-Onset Still's Disease Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia + Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased glycosylated fraction < 20% Differential Diaqnoses: • Infectious: Mycoplasma, yersinia, borrelia, Rubeola, HBV, Coxsackie, CMV, EBV, HIV, HTLVI, Hantavirus • Malignant hemopathies, solid cancers • Systemic diseases : other autoinflammatory diseases (mevalonate kinase deficiency, Schnitzler) Complications: MAS, Visceral, DIC, TMA • Cardiac: pericarditis, rhythm abnormalities, conduction abnormalities • Muscular: normal CK, normal biopsy • Lymphadenopathies, splenomegaly • Hepatic: hepatomegaly, hepatitis • Pulmonary: pleural effusion, infiltrates • Neurological: meningoencephalitis, . • Ocular: uveitis, episcleritis By Dr. Prunelle Getten #AdultOnset #Stills #Disease #diagnosis #management #treatment #rheumatology
