HHV8/KSHV-reIated diseases: From Cellular Proliferation to Hyperinflammation Kaposi sarcoma (KS): • Target organs: Ubiquitous (cutaneous and mucosal predominance) • Clinical features: Blue-violet macules or nodules (+/- according to visceral involvement) • Histology: LANA+ fusiform cells (*) from endothelium • Association HIV/EBV: Yes/No • Clonality: Polyclonal (except nodular forms) • Light chain: - HHV8+ Multicentric Castleman Disease (MCD): • Target organs: Lymph nodes and spleen • Clinical features: Fever, adenopathies (ADP), splenomegaly, effusion, hemophagocytosis • Histology: LANA+ plasmablasts from pre-GC B cells • Association HIV/EBV: Yes/Rare • Clonality: Polyclonal • Light chain: Constant λ Monotype Primary effusion lymphoma (PEL): • Target organs: Pleural, pericardial, peritoneal cavities • Clinical features: Effusion, B symptoms • Histology: LANA+ immunoblastic/anaplasic cells from differentiated B cells • Association HIV/EBV: Yes / Yes • Clonality: Monoclonal • Light chain: Monotype By Dr. Gregoire Martin de Fremont #HHV8 #diseases #comparison #diagnosis #kshv #kaposi #humanherpesvirus
