Warm Antibody Autoimmune Hemolytic Anemia 1) DIAGNOSE AIHA • Anemia: macrocytic > normocytic, ↑ reticulocytes • Hemolysis: ↓ haptoglobin ↑ indirect bilirubin, ↑ LDH • Anti-RBC autoantibodies: positive direct Coombs • IgG type ± C3d • Blood smear: Differential → schizocytes, Positive → spherocytosis 2) LOOK FOR a cause → Systematic screening 3) TREAT AIHA 1 - Glucocorticoids 2 - Rituximab +++ 3 - Splenectomy 4 - Immunosuppressive agents By Dr. Clara Pouchelon #Warm #Antibody #Autoimmune #Hemolytic #Anemia #diagnosis #management #treatment #rheumatology
