Bradykinin-mediated Angioedema Clinical features: Submucosal oedema (face, extremity, genitalia), Laryngeal dyspnea (25% of deaths), Recurrent attacks of abdominal pain Types: • Hereditary, • Acquired: lymphoproliferative disorders (MGUS), autoimmune disease (lupus) • Iatrogenic: ACEI (black people, concomitant DPP4 or rapamycin inhibitors), thrombolytic therapy (ischemic stroke, female, ACEI) Bradykinin vs. histamin-mediated AE: • Absence of atopic disorders • Genitalia involvement, abdominal pain • Absence of pruritus, urticaria, low BP bronchospasm • Duration of attacks: >24 hours • Steroids/antihistamines ineffectiveness • Specific treatment effectiveness By Dr. Clara Vigneron #Bradykinin #mediated #Angioedema #allergy #immunology #diagnosis #management #treatment
