Management of Lupus Nephritis
Lupus nephritis (LN) in 10 to 40% of SLE
Hallmark = proteinuria 20.5 g/g or 0.5 g/day → renal histological evaluation to determine LN severity (ISN/RPS classification) and the need for specific therapy
Goal: proteinuria <0.5-0.7 g/g by 12 months
Classification:
• Class I - Minimal mesangial LN
• Class II - Mesangial proliferative LN
• Class Ill - Focal LN (<50% of glomeruli)
III (A) : active
Ill (NC) : active and chronic lesions
Ill (C) : chronic lesions
• Class IV - Diffuse LN (>50% of glomeruli)
Diffuse segmental (IV-S) or global
(IV-G) LN
IV (A) : active lesions
IV (A/C) : active and chronic lesions
IV (C) : chronic lesions
• Class V - Membranous LN
• Class VI - Advanced sclerosing LN
By Dr. Chloé Baillou @BaillouChloe
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