Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% - Photosensitivity 29% - Raynaud's 18% - Serositis 17% - Nephropathy 16% - Oral ulcers 11% - Neurological 12% - Thrombocytopenia 9% - Lymphadenopathies 7% - Hemolytic anemia 4% - Myositis 4% - Lung involvement 3% SLE-Related Auto-Antibodies: - ANA 95-100% - Anti-dsDNA 60-80% - Anti-nucleosome 60-70% - Anti-histone 60-70% - Anti-SSA 30-40% - Anti-SSB 5-10% - Anti-(U1)RNP 15-30% - Anti-Sm 10-30% - Anti-RiboP 5-15% - Anti-Ku 5-10% - Anti-PCNA 1-5% - Anti-cardiolipin (aPL) 30-70% - Anti-B2GP1 (aPL) 30-45% Differential Diagnosis and Lupus Mimickers: Drug-induced lupus, Cutaneous mimickers, Other auto-immune, Infectious diseases, Hematological malignancies, Multiple sclerosis, Still's disease Dr. Laurent ARNAUD @Lupusreference #SLE #Systemic #Lupus #Erythematosus #Diagnosis #autoantibodies #signs #symptoms #mimickers #differential #rheumatology
