Hydroxychloroquine Serum Measurement in SLE • Terminal elimination half-life = 40 days ([HCQI reflects long-term intake) • Target blood concentration: > 750ng/mL and probably < 1500ng/mL • Non-adherence (or rarely severe malabsorption) if < 200ng/mL Best indications: • To check therapeutic adherence (randomly or when suspected) • In case of flare (poor therapeutic adherence? Insufficient blood levels?) • Special cases (e.g. renal failure) Dr. Laurent ARNAUD @Lupusreference #Hydroxychloroquine #HCQ #Serum #Measurement #SLE #rheumatology #pharmacology #levels #lupus #management
