Antinuclear antibodies and Systemic lupus Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can also be measured using ELISA-based or IF on Crithidia Luciliae Anti-nucleosome 60-70% Highly specific for SLE. Often searched for when ANA+ without anti-dsDNA Anti-histone 60-70% Association with both SLE (60-70%) & drug-induced lupus (90%) Anti-SSA 30-40% Target: SS-A/Ro (60kD). Associated with SCLE, neonatal lupus and Sjogren Anti-SSB 5-10% Associated with Sjogren and neonatal lupus Anti-(U1)RNP 15-30% Associated with MCTD and Raynaud's phenomenon Anti-Sm 10-30% Highly specific. Higher prevalence in non-white (30%-40%) than white (5-10%) Anti-Ribo-P 5-15% If SLE is clinically suspected, tests to ribosomal P phosphoproteins (P0, P1, P2, C22 RibP peptide) are recommended*. Controversial association with NPSLE. Anti-Ku 5-10% Associated with SLE-SSc-AlM overlap syndromes Anti-PCNA 1-5% Considered higly specific for SLE (debated) Anti-DFS70 0-3% Rarely confirmed in patients with typical SLE. Negative association with auto-immune diseases only if Ag target is LEDGF/p75 and there is no common ENA* Dr. Laurent ARNAUD @Lupusreference #Antinuclear #autoantibodies #Systemic #lupus #erythematosus #diagnosis #rheumatology #table #ANA
