Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary
• Epidemiology: 10-180/100,000, Typically Age 20-40, F:M 9:1
• Clinical Manifestations: Malar rash, Photosensitivity, Alopecia, oral ulcers, Lupus nephritis, NPSLE - If present, are evocative of SLE versus DIL
• Laboratory Manifestations:
- CRP: Usually normal (except with serositis)
- Cytopenia: Common
• Immunologic Workup:
- ANA >
- Anti-ENA - Positive in up to 30%
- Anti-dsDNA - Positive in 60-80% of cases
- Anti-histone - Positive in 60-80%
- Low complement - 50-60%
- pANCA anti-MPO - Negative
• Prognosis: Minor to life-threatening
• Treatment: Usual therapeutic management of SLE
• Evolution: Chronic disease
Dr. Laurent ARNAUD @Lupusreference
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