Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is approximately how long (in days) it takes a reticulocyte to transform into a RBC once released in the peripheral blood at a particular degree of anemia. Hypoproliferative (i.e. bone marrow not responding appropriately)- Retic Index < 2: • Anemia of chronic inflammation • Nutrient deficiencies: Iron deficiency (including chronic blood loss), Vitamin B12, Folate • Hormone deficiencies: Chronic kidney disease, Hypothyroidism, Hypogonadism • Bone marrow failure: Aplastic anemia, Marrow infiltration (e.g. cancer, infection), Marrow suppression (e.g. drugs, chemotherapy, radiation) • "Hospital-acquired anemia" Hyperproliferative (i.e. bone marrow responding appropriately) - Retic Index > 3: • Acute blood loss: Trauma, Gl bleed, Retroperitoneal, Uterine • Hemolysis: Autoimmune, Microangiopathic hemolytic anemia, Intrinsic RBC defects (e.g. sickle cell anemia, G6PD deficiency), Infections, Hypersplenism - Dr. Eric Strong @DrEricStrong - Strong Medicine https://www.youtube.com/c/EricsMedi #Reticulocyte #Production #Index #hematology #anemia #differential #diagnosis #calculation
