Primary Biliary Cirrhosis - Diagnosis Algorithm Symptoms: Fatigue, Pruritus, Right upper quadrant discomfort Signs: Jaundice, Xanthelasmata, Hepatomegaly Associated history: Symptoms of associated autoimmune disease (e.g. dryness of the eyes and mouth, Raynaud's phenomenon, arthritis), Personal/family history of autoimmune disease, Persistent pruritus after pregnancy Diagnose PBC if 2/3 criteria are met: 1. Elevated ALP 2. Positive AMA or specific ANAs (e.g. gp210/sp100) 3. Liver biopsy findings consistent with PBC #PBC #Primary #Biliary #Cirrhosis #Diagnosis #Algorithm #hepatology
