Celiac Disease - Diagnosis Algorithm IgA TTG has high sensitivity and specificity of ~ 98% and is the best serologic marker for evaluating CD. IgA deficiency affects 2%–3% of CD patients. If IgA def ---> check IgG deamidated gliadin peptide First degree relatives have inc risk of celiac. As do pts with DM1, Down’s, Turner’s, and Williams’ syndromes. Ruling out celiac in pts with IBS-D is recommended. In pts already on a GFD--> check HLA DQ2 or DQ8 to identify which pts need further testing. -A negative test essentially rules out celiac. -A positive test however, does not establish a diagnosis since this can be seen in the general population. - Gastroenterology Review @GIreview #Celiac #Disease #Diagnosis #Algorithm #gastroenterology #workup
