ISTH Scoring System for Disseminated Intravascular Coagulation (DIC) Platelet count: • Expected: Low (or normal) • Elevation in thrombin → thrormbin-induced platelet aggregation PT, aPTT: • Expected: Elevated • Decreases due to consumption of coagulation factors, Can be normal since the presence of thrombin and factor Xa can accelerate thrombin formation, DO NOT monitor using INR use PT D-dimer: • Expected: Elevated • Elevated as this is a product of fibrinolysis Fibrinogen: • Expected: Low (or normal) • Is broken down by thrombin to form clots, Can be normal as fibrinogen is also an acute-phase reactant Blood smear: • Expected: Schistocytes • Intra-luminal deposition of fibrin leads to shearing of RBCs as they pass through small vessels #DIC #Disseminated #Intravascular #Coagulation #ISTH #Scoring #diagnosis #hematology #laboratory
