Eosinophilic Esophagitis (EoE) - Spectrum of Response
Non-response:
• Histology: Persistent eosinophilia, ≥ 15 eos/hpf
• Symptoms: Persistent symptoms, <30% decrease in a symptom metric
• Endoscopy: Persistent endoscopic findings, <30% decrease in EREFS
Response:
• Histology: Reduced eosinophilia, 7-14 eos/hpf 1-6 eos/hpf
• Symptoms: Decreased symptoms, 30-90% decrease in a symptom metric
• Endoscopy: Improved findings, EREFS score ≥2 but less than baseline
Complete Normalization:
• Histology: Normal biopsy, <1 eos/hpf
• Symptoms: Symptom resolution, >90% decrease in a symptom metric; EEsAl score < 20
• Endoscopy: Normal esophagus, EREFS score < 2
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