Amebiasis - Naegleria fowleri - Life Cycle 1) Cysts 2) Trophozoite 3) Flagellated Form 4) Promitosis → Water-related activities such as swimming underwater, diving, or other water sports can result in water entering the nose → 5) Amebae penetrate the nasal mucosa 6) Amebae migrate to the brain via the olfactory nerves causing primary amebic meningoencephalitis (PAM) in healthy individuals → Trophozoites in CSF and brain tissue; flagellated forms occasionally in CSF #Amebiasis #Naegleria #fowleri #LifeCycle #diagnosis #pathophysiology #infectiousdiseases #cdc #parasite