Leishmaniasis Life Cycle 1) Sandfly takes a blood meal (injects promastigote stage into the skin) Human Stages: 2) Promastigotes are phagocytized by macrophages or other types of mononuclear phagocytic cells 3) Promastigotes transform into amastigotes 4) Amastigotes multiply in cells of various tissues and infect other cells Sandfly Stages: 5) Sandfly takes a blood meal (ingests macrophages infected with amastigotes) 6) Ingestion of parasitized cell 7) Amastigotes transform into promastigote stage in the gut 8) Divide in the gut and migrate to proboscis #Leishmaniasis #LifeCycle #diagnosis #pathophysiology #infectiousdiseases #cdc #parasite
