Multiple Myeloma Diagnosis and Management Summary Clinical Signs: • hyperCalcemia 28% (bone demineralization) • Renal disease 48% (light chain cast nephropathy and hypercalcemia) • Anemia 78% (bone marrow replacement) - Usually normocytic but can be macrocytic • Bone pain 58% (osteolytic lesions and pathologic fx) Diagnosis - Clonal bone marrow plasma cells >10% plus one of: • Anemia. Hgb < 10 • Ca > 11 • Creatinine > 2 • >5mm osteolytic lesion • >60% plasma clonal cell in bone marrow • FLC ratio >100 if FLC value is also >100 CMC IM Residency @CMC_IM #Multiple #Myeloma #Diagnosis #Management #oncology
