Fusarium Treatment • Antifungal "susceptibility" can vary with Fusarium spp • F. oxysporum: low MICS to amphotericin • F. solani: higher in vitro MICS for amphotericin • Prognosis and response to antifungals is tied to immune status • Recovery of neutropenia is key > uniformly lethal without this Therapeutic options for disseminated disease: • Optimal treatment not established, no prospective trials • Most experts recommend lipid formulations of amphotericin B for severe cases; triazole (e.g., voriconazole, posaconazole, isavuconazole) for mild/moderate Tx in setting of endophthalmitis: • Surgical removal of vitreous (vitrectomy) is nearly always necessary • Depending on the type of injury (i.e. open globe), pt might require enucleation Infectious Diseases Fellows Network @ID_fellows #Fusarium #Infections #infectiousdiseases #management #treatment
