Morphology and Descriptions of Fungal Infections with Hyphae or Pseudohyphae in Tissues Yeasts with Pseudohyphae: • Description: Small yeasts (3-5 microns In size) intermingled with pseudohyphae and hyphae • Consistent with Candida spp. however Aspergillus spp. and other hyaline fungi can be confused histologically Non-pigmented (hyaline), septated hyphae: • Description: acute angle branching • Consistent with Aspergillus spp, Fusarium spp, Scedosporium spp, Trichoderma spp, paecilomyces spp and others. Mucorales genera can sometimes have this morphology Non-pigmented (hyaline), Pauciseptate Hyphae: • Description: pauciseptate ribbon-like hyphae with right angle branching • Consistent with Mucorales genera; however Asperglllus spp. and other septated hyaline hyphae can sometimes have this Pigmented Yeasts and Hyphae with Septations: • Description: pigmented irregular hyphae and yeast-like structures both with septations • Consistent with dematiaceous fungi including: Madurella spp, Fonsecaea spp, Cladophialophora spp, Exophiala spp, Curvularia spp, Bipolaris spp, and others Dr. Sara Dong @swinndong #Hyphae #Pseudohyphae #fungal #fungi #infections #microbiology #differential #diagnosis #morphology #septae #septations #pathology #atlas
