Hemolytic Anemia - Differential Diagnosis Algorithm Hereditary: • Peripheral blood smear + DAT + further History • Bite cells, Heinz bodies, DAT (-) → G6PD Deficiency • Sickle cells, DAT (-) → Sickle Cell anemia • Hypochromic & microcytic RBCs, DAT (-) → Thalassemia • Spherocytes, DAT (-) FHx? → Hereditary spherocytosis Acquired: • Spherocytes, DAT(+) → Immune mediated hemolysis (idiopathic, malignancy, autoimmune disease, drugs, transfusions) • Schistocytes DAT(-) → Microangiopathic hemolytic anemia (TTP, HUS, DIC, eclampsia, malignant HTN) • Recent travel/Fevers, DAT (-) → Infection mediated (Babesiosis. Malaria, Clostridium) Unremarkable Labs @UnremarkableLab #Hemolytic #Anemia #Differential #Diagnosis #Algorithm #causes
