Causes of Hypercalcemia due to increased Vitamin D levels
• The BIG 3:
- Lymphoma
- Sarcoidosis
- Tuberculosis
• Fungal Infections: Pneumocystis jiroveci, Histoplasmosis, Coccidioidomycosis, Paraccocidioidomycosis, Candidiasis
• Other granulomatous diseases: PR3+ vasculitis, Crohn's disease, Acute granulomatous pneumonia, Talc granuloma, Silicone-induced granuloma, BCG-associated granulomatous hepatitis, Paraffin-associated granuloma
• Genetic: Williams syndrome, Pseudoxanthoma elasticum, CYP24A1 mutation (adult / infantile), SLC34A1 mutation
• Miscellaneous: Excessive vitamin D ingestion, Mycobacterium avium, Leprosy, Lipoid pneumonia, Cat scratch fever, Berylliosis
Dr. Jamie Willows @jamiekwillows
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