Complications of Monoclonal Gammopathy of Undetermined Significance (MGUS) Fracture, Osteoporosis - Increased osteoclast activity and bone resorption - Bone protection with bisphosphonates Infection - Hypogammaglobulinaemia Reduction in specific antibody - Early treatment of infective symptoms; vaccinations Renal disease - Monoclonal Ig deposition disease, proliferative glomerulonephritis, light-chain proximal tubulopathy - Dependent on mechanism: chemotherapy Neuropathy - Antibodies against myelin-associated glycoprotein (MAG) in myelin sheath of peripheral nerves - IV immunoglobulin; chemotherapy; rituximab (in clinical trials) Thrombosis - Inflammation related: raised inflammatory mediators, including IL-6 - Consideration of thromboprophylaxis in high-risk situations #MGUS #Monoclonal #Gammopathy #Complications #diagnosis #hematology
