Gastrointestinal Stromal Tumor (GIST)
Most prevalent intramural gastric tumor
Arises from interstitial cells Of (EUS layer 4)
Has higher risk of malignancy than leiomyoma (10-30%)
CD117 (c-kit) = POSITIVE
Smooth muscle actin negative, Vimentin negative, S100 = negative
Prognosis - Rule of 5's:
> 5 cm OR > 5 mitoses/50 HPF → Intermediate-risk
> 5 cm AND > 5 mitoses/50 HPF → High-risk Gastric GIST
Treatment:
• If < 2 cm can consider endoscopic removal, including band ligation
• If > 2cm — recommend surgical resection
• Clearly unresectable or > 5 cm AND > 5 mitoses/50 HPF = imatinib
Dr. Shoukat Ali @DrShoukatAli16
#GIST #Gastrointestinal #Stromal #Tumor #diagnosis #gastroenterology #management
