Probiotics Guidelines Adults with C difficile infection • Recommendation: Only in the context of a clinical trial • Evidence: Knowledge gap Adults and children on antibiotic treatment • Recommendation: Conditional • Evidence: Low Adults and Children with Crohn's disease • Recommendation: Only in the context of a clinical trial • Evidence: Knowledge gap Adults and children with ulcerative colitis • Recommendation: Only in the context of a clinical trial • Evidence: Knowledge gap Adults and children with pouchitis • Recommendation: Conditional • Evidence: Very low Children and adults with irritable bowel syndrome • Recommendation: Only in the context of a clinical trial • Evidence: Knowledge gap Children with acute infectious gastroenteritis • Recommendation: Against • Evidence: Moderate Preterm (less than 37 weeks gestational age), low birth weight infants • Recommendation: Conditional • Evidence: Moderate/high DOI: 10.1053/j.gastro.2020.07.025 #Probiotics #Guidelines #gastroenterology #indications #recommendations #management #evidence #ebm