Hypokalemia Differential Diagnosis Algorithm
Hypertensive:
• High Al, Low R - Primary aldosteronism
• High Al, High R - Secondary Hyperaldosteronism: malignant HT, renovascular HT, Renin-secreting tumor
• Low Al, Low R - Pseudo-hyperaldosteronism: exogenous mineralocorticoids, glycyrrhizic acid, Liddle's Syndrome, Congenital Adrenal Hyperplasia
• Normal Al, Normal R - Cushing's syndrome
Normotensive:
• UCl- <20 mEq/24 h - Vomiting, Nasogastric drainage, Post-hypercapnia
• UCl- >20 mEq/24 h - Diuretics, Bartter's syndrome, Gitelman's syndrome
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