Pharmacologic Management of Constipation Commonly used laxatives: • Bulk-forming laxatives - Psyllium, methylcellulose, polycarbophil • Osmotic laxatives - Sodium phosphate, polyethylene glycol, sorbitol, lactulose, magnesium hydroxide, magnesium citrate, magnesium sulfate • Stimulants - Diphenylmethane derivatives (bisacodyl, sodium picosulfate), anthraquinones (sennoside, aloe, cascara) • Stool softeners - Docusate sodium, docusate calcium • Lubricants - Mineral oil Newer agents: • Chloride channel activators - Lubiprostone • Guanylate cyclase C receptor agonists - Linaclotide, plecanatide • Selective serotonin 5-HT4 receptor agonists - Prucalopride, cisapride, tegaserod • Ileal bile acid transporters inhibitors - Elobixibat #Constipation #Management #treatment #medications #pharmacology
