Amiodarone Thyroid Complications Amiodarone: - iodine-rich, similar structure to T4, with half life up to 100d - inhibits conversion ofT4 to T3 - can prevent T4/T3 from entering peripheral tissues - can be directly toxic to thyroid follicular cells • Amiodarone Induced Thyrotoxicosis Type I - Typically in pts w/ latent thyroid dz: iodine load leads to excess thyroid hormone synthesis (Jod-Basedow phenomenon) • Amiodarone Induced Thyrotoxicosis Type II - Typically in pts w/ normal thyroid: amiodarone leads to destructive thyroiditis • Amiodarone Induced Hypothyroidism - Typically in pts w/ underlying thyroid dz: unable to "escape" from the Wolff-Chaikoff effect (iodine load suppresses thyroid hormone production and release) Dr. Khurrum Khan @KhurrumKhanMD #Amiodarone #Thyroid #Complications #endocrinology #diagnosis #pharmacology
