Warm vs Cold Autoimmune Hemolytic Anemia Warm Autoimmune Hemolytic Anemia: • Mechanism: IgG and Complement-mediated • Etiology: Lymphoproliferative disorder, Autoimmune disorder • Associated Findings: Coombs positive for IgG +/- C3, Spherocytes • Treatment: Corticosteroids, Immunosuppression, Splenectomy Cold Autoimmune Hemolytic Anemia: • Mechanism: IgM and Complement-mediated • Etiology: Lymphoproliferative disorder, Mycoplasma, HIV, EBV • Associated Findings: Coombs Positive for C3 only, Agglutination, Mostly transient hemolysis • Treatment: Warm patient, Plasmapheresis - VA Joint Chiefs @BostonChiefs #Warm #Cold #Autoimmune #Hemolytic #Anemia #hematology #diagnosis #comparison
