Myositis and Myopathies Polymyositis • Progressive, symmetric muscle weakness • Elevated CK, +Anti-Jo, +Anti-Mi2 Dermatomyositis • Progressive, symmetric muscle weakness, rash • Elevated CK, +Anti-Jo, +Anti-Mi2 Polymyalgia Rheumatica • Pain and stiffness in proximal joints, Fever, No muscle weakness • Elevated ESR, Normal CK, associated with temporal arteritis Inclusion Body Myositis • Slow onset, asymmetric muscle weakness • Normal or mildly elevated CK, Biopsy: inclusions, rimmed vacuoles HIV myopathy • Proximal muscle weakness • Elevated CK, Detectable HIV viral load Drug-induced myopathy • Alcohol, Steroids, Statins, Cocaine, Chloroquine, Colchicine, Anti-retrovirals, Gemcitabine Lupus Myopathy • Diffuse muscle pain and/or joint aches • +ANA, +Anti-Smith, +Anti-dsDNA, Myositis: elevated CK (uncommon 5-15% of lupus myopathy) VA Joint Chiefs @BostonChiefs #Myositis #Myopathies #myopathy #differential #diagnosis #comparison #rheumatology
