Primary and Secondary Causes of Mitral Regurgitation Primary (organic) chronic mitral regurgitation: • Leaflet: Rheumatic fever, Infective endocarditis, Myxomatous (MVP), Connective tissue (Marfan, Ehlers-Danlos), Congenital (cleft, cushion defects), Systemic inflammation (SLE, Scleroderma) • Chordae tendineae: Rheumatic fever, Infective endocarditis, Myxomatous (MVP), Spontaneous rupture • Mitral annulus: Rheumatic fever, Calcification (idiopathic), Myxomatous (MVP), Connective tissue (Marfan, Ehlers Danlos) • Prosthetic valve: Paravalvular leak, Infective endocarditis, Ring fracture, Thrombus formation, Leaflet deterioration, Occluder dysfunction Secondary (functional) chronic mitral regurgitation: • Leaflet: Hypertrophic cardiomyopathy, Drug-related • Chordae tendineae: Myocardial infarction, Tendineae rupture • Papillary muscle: Myocardial infarction, Dilated cardiomyopathy, Papillary muscle rupture, Left ventricular aneurysm • Mitral annulus valve: Dilated cardiomyopathy - VA Joint Chiefs @BostonChiefs #Mitral #Regurgitation #differential #diagnosis #cardiology #causes #primary #secondary
