Important Cardiac Transplant Medications and Side Effects • Cyclosporine (Sandimmune, generic) - Calcineurin inhibitor, decreasing T lymphocyte activity and IL2 • Tacrolimus (Prograf) - Calcineurin inhibitor, inhibiting T lymphocyte activity and IL2 • Azathioprine (Imuran) - Block nucleotide production for immune cell replication • Sirolimus (Rapamune) - Blocks mTOR receptor and immune cell signal transduction, reducing B and T cell activity • Polyclonal antibodies (antithymocyte gamma-globulin) - Antilymphocyte antibody • Monoclonal antibodies (OKT3, IL2-receptor antibody) - Antilymphocyte antibody - Used for prophylaxis against rejection in early period • Corticosteroids - Impairs phagocyte function - Attenuates production of pro-inflammatory mediator, Decreases T cell activity, Decreases cell signal transduction - Alin Gragossian, DO, MPH @AG_EM33 #Cardiac #Transplant #Medications #drugs #pharmacology #heart
