Fungal Biomarkers: Comparing Beta-D-Glucan and Aspergillus Galactomannan Beta-D-Glucan: • Polysaccharide cell wall component of many fungi • Pathogens: Candida, Aspergillus • Other Pathogens: PCP, Histoplasma. Fusarium, Acremonium, Scedosporium, dermatophytes • Sens ~55-96%, Spec ~77-96% Aspergillus Galactomannan: • Major polysaccharide constituent of Aspergillus cell walls • Pathogens: Aspergillus • Other Pathogens: Fusarium, Penicillium, Histoplasma, Blastomyces, Paecilomyces, Cryptococcus • Sens/Spec -80% for IA, PPV < 50%, NPV > 90% by Dr. Sara Dong @swinndong via Febrile @febrilepodcast #Fungal #Biomarkers #BetaDGlucan #Aspergillus #Galactomannan #diagnosis #comparison #microbiology
