Clinical Manifestations of Serotonin Syndrome • Ophthalmologic: Mydriasis, Ocular clonus (slow horizontal movements) • Gastrointestinal: Diarrhea, increased bowel sounds, RUQ pain • Dermatologic: Diaphresis, flushing • CNS: Agitation, Delirium, Rigidity, Hyperreflexia • Cardiovascular and vital sign abnormalities: Tachycardia, Fever, Hypertension, Late stages (shock) Spectrum of Clinical Manifestations (Mild → Life-Threatening): Akathisia, Altered Mental Status (agitated), Tremor, Clonus (sustained), Clonus (inducible), Muscular Hypertonicity, Hyperthermia UCSD Internal Medicine @ucsdim #Serotonin #Syndrome #Symptoms #spectrum #signs #diagnosis
