Immune Reconstitution Inflammatory Syndrome (IRIS) - Pathophysiology Risk factors: - Low CD4 count - Disseminated OI - Paucity of inflammatory response to OI (in CM) - Short duration or OI treatment Possible mechanisms: - Uncoupling of innate and acquired immunity - Restoration of exuberant pathogen-specific cellular immune responses - Defective or delayed regulatory responses UCSD Internal Medicine @ucsdim #Immune #Reconstitution #Inflammatory #Syndrome #IRIS #Pathophysiology #AIDS