Hypercalcemia - Differential Diagnosis Algorithm
Elevated PTH (High or normal):
• Primary Hyperparathyroidism
• Familial Hypocalciuric Hypercalcemia
Low PTH:
• Elevated Calcitriol (1,25 OH Cholecalciferol)
- ↑ 250H Cholecalciferol - Excess Vitamin D Intake
- ↓ 25OH Cholecalciferol - Granulomatous Disease, Lymphoma (Hodgkin)
• Elevated PTHrp
- Solid Tumors: Lung, SCC, renal, Bladder, Breast, Ovarian
- Leukemia/Lymphoma: NHL, CML
• Miscellaneous
- Bone Resorption: Hyperthyroid, Bony Mets
- Calcium Reabsorption: Thiazides/Lithium
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