TRALI vs TACO - Transfusion Reactions TRALI: • Epidemiology: 0.1% of transfused patientsl • Risk factors: Critical illness, high plasma volume transfusion, female of high parity blood donor • Pathophysiology: 2 hit mechanism of neutrophil sequestration and activation • Timing: Within 6 hours of transfusion • Criteria: ARDS Berlin Criteria met without other cause of ARDS to explain symptoms • Fever and hypotension?: 33% • Treatment: Supportive TACO: • Epidemiology: 0.3-8% of transfused patients • Risk factors: Age>60, CKD, CHF, high rate and/or volume of transfusion • Pathophysiology: Volume overload • Timing: Within 6 hours of transfusion • Criteria - At least 3 of (Acute resp distress, elevated BNP, high CVP, left heart failure, positive fluid balance, and CXR with pulmonary edema) • Fever and hypotension?: No • Treatment: Supportive + diuresis SCVMC Internal Medicine @SCVMCMed #TRALI #TACO #Transfusion #Reactions #hematology #diagnosis #comparison #table
