Thyrotoxic Periodic Paralysis - Illness Script • Epidemiology: Asian men age 20-30 with hyperthyroidism of any etiology • Trigger: Heavy exercise, fasting, high-carb meals, stress, cold exposure, infection, alcohol, pulse corticosteroid therapy, albuterol, and menses • Pathophysiology: Channelopathy due to hypersensitization of the Na-K pump by excess thyroid hormone • Symptoms/signs: Episodes of sudden onset painless muscle weakness that are infrequent, hours-days duration +/- symptoms of thyrotoxicosis • Labs/lmaging: Hypokalemia +/- low TSH with high fT4 or high T3 • Treatment: Potassium and magnesium repletion, Avoid triggers, Treat hyperthyroidism, Potassium supplements and propranolol for prevention of future episodes #Thyrotoxic #Periodic #Paralysis #diagnosis
