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Chronic Hypercapnic Respiratory Failure Phenotypes Pink Puffers (robust vent drive) ↑ their WOB when pulmonary mechanics gradually worsen (despite the caloric cost) → pulmonary cachexia Blue Bloaters (blunted vent drive) maintain the same WOB when pulmonary mechanics gradually worsen (despite the CO2 rise) → chronic hypercapnia Landsberg Manual @LandsbergManual - https://amzn.to/3rEtbK8 #Hypercapnic #Respiratory #Failure #Phenotypes #COPD #diagnosis