Hepatorenal Syndrome (HRS) - Diagnostic Criteria
HRS-AKI (Acute: previously known as HRS Type 1)
• ↑ Creatinine by 0.3 mg/dL (27 μmol/L) in 48h or by 50% in 3 months
• Cirrhosis + ascites
• No response to 1 g/kg/d of HAS x 48h (60kg patient: 3x 100ml 20% HAS)
• No shock
• No nephrotoxics (e.g. diuretics, NSAIDs)
• No structural kidney injury: No proteinuria (>500mg/d), No haematuria, Normal renal ultrasound
HRS-NAKI (Non-Acute: previously known as HRS Type 2)
• HRS-AKD
- ↑ Creatinine by 50% in 3 months
- eGFR < 60ml/min/1.73m2
- No other cause of kidney disease
- Cirrhosis + ascites
• HRS-CKD
- eGFR < 60ml/min/1.73m2
- No other cause of kidney disease
- Cirrhosis + ascites
Dr. Keith Siau @drkeithsiau
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