Differential diagnosis of schistocytes / fragmentation hemolysis:
• Thrombotic microangiopathies (TMA)
- TTP
- Shiga toxin-mediated hemolytic-uremic syndrome (ST-HUS)
- Complement-mediated TMA (formerly known as atypical HUS)
- Drug-induced thrombotic microangiopathy (DITMA)
- TMA after solid organ or stem cell transplant
• DIC / Trousseau's
• Malignant hypertension
• Scleroderma renal crisis
• Severe B12 deficiency
• Mechanical hemolysis/"macroangiopathic hemolytic anemia"
• HELLP syndrome
• Catastrophic APLS
BCM IM Residency @BCM_InternalMed
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