Hemophagocytic Lymphohistiocytosis (HLH) Clinical Features: Fever, Splenomegaly, Hepatomegaly, Lymphadenopathy, Confusion Classic lab findings in HLH: ↑↑ ferritin, Anemia, Thrombocytopenia, Neutropenia, ↑ AST & ALT, ↑ LDH, ↓ Fibrinogen & ↑ d-dimer, ↓ NK cell activity, ↑ soluble IL-2 receptor Diagnostic Criteria for HLH (The Histiocyte Society Criteria): Molecular diagnosis consistent with HLH OR Meeting ≥ 5 of the following 8 criteria: • Fever • Splenomegaly • Cytopenias (affecting 2 2 cell lines) • ↑ ferritin • ↑ triglycerides and/or ↓ fibrinogen • ↓ NK activity • ↑ soluble IL-2 receptor • Hemophagocytosis on biopsy - Dr. Eric Strong @DrEricStrong - Strong Medicine https://www.youtube.com/c/EricsMedi #HLH #Hemophagocytic #Lymphohistiocytosis #diagnosis #hematology #criteria
